Topic: IV injectable medicines guide
Pages: 1, Double spaced
Order type: Coursework
Language: English (U.S.)
IV Injections: Stability, compatibility, Incompatibility and Mode of Administration
Points of note:
1. Extravasation of the drug may cause tissue injury
2. Reconstituted/dilute drugs with the recommended solutions
3. Some drugs have a single use life whereas others can be stored at specialized conditions for a certain period of time before usage
4. Follow drug administration carefully
5. Monitor the patient for adverse events and efficacy of the drugs
AbbVie Limited. (03 August, 2015). Chirocaine 2.5mg/ml solution for injection/concentrate for solution for infusion.
Actavis Limited. (28 April 2016). Diltiazem hydrochloride.
Amdipharm. (December 2013). Apresoline (Hydralazine) 20mg powder for concentrate for solution for injection/infusion.
Aspen Pharma Trading Limited. (2012). Lanoxin Injection (Digoxin). Aspen, Lake Drive: City West Business Campus, Dublin 24, Ireland. Manufactured by GlaxoSmithKline Manufacturing S.p.A., San Polo di Torrile, Parma, Italy.
Aspen. (31 January 2017). Diprivan 10 mg/ml (1%) emulsion for injection or infusion.
Aspen. (September 2012). Arixtra Fondaparinux sodium solution for injection 2.5 mg/ 0.5 ml or 7.5 mg/ 0.6ml.
AstraZeneca Limited. (26 January 2017). Meronem IV 500mg & 1g. Sodertalje, Sweden.
AstraZeneca. (February 2012). Naropin 2mg/ml, 7.5mg/ml, 10mg/ml solution for injection (Ropivacaine hydrochloride monohydrate). Sodertalje, Sweden.
Aurum Pharmaceuticals limited. (31 January 2017). Acetylcysteine 200 mg/ml injection: Acetylcysteine. Bampton Rd., Harold Hill, Rumford: United Kingdom
B.Braun Melsungen AG. (November 2005). Bactrim for infusion Co-Trimoxazole.
Baxter Healthcare Corporation. (31 august 2010). Brevibloc (esmolol Hydrochloride 10 mg/ml solution for injection). Deerfield, USA.
Baxter Healthcare Limited. (December 2016). Metronidazole Fresenius solution for infusion (1ml contains 5mg metronidazole; each 100ml vial contains 500mg metronidazole).
Bayer. (September 2016). Ciprobay (Ciprofloxacin) 2mg/ml (200mg/100ml) solution for infusion.
BGP products limited. (10 November 2009). Klacid IV 500mg powder for concentrate for solution for infusion. Abbot House, Vanwall Business Park. Maidenhead, Berkshire, United Kingdom.
BGP Products limited. (February 2015). Securon IV 2.5 mg/ml aqueous solution for intravenous injection: Verapamil hydrochloride BP. Abbot House, Vanwall Business Park. Maidenhead, Berkshire, United Kingdom.
Biotest Limited. (February 2016). Intratect 100g/l solution for infusion: Human normal Immunoglobulin (IVIg).
Bodene (PTY) Limited. (10 December 2008). Chlorpromazine HCl-Fresenius 25mg/1ml (Injection) Or Chlorpromazine HCl-Fresenius 50mg/2ml (Injection). Bodene trading as Intramed, 6 Gibaud Road, Port Elizabeth: South Africa.
Boehringer Ingelheim limited. (September 2015). Actilyse 10 mg, 20 mg and 50 mg powder and solvent for solution for injection and infusion. Boehringer Ingelheim Interntaional GmbH, Ingelheim am Rhein: Germany.
Bristol-Myers Squibb Pharmaceutical Limited. (October 2014). Perfalgan 10mg/ml solution for infusion.
Chiesi Limited. (February 2015). Peyona (caffeine citrate) 20 mg/ml solution for infusion and oral solution. Via Palermo, Italy.
Concordia international. (01 March 2013). Haldol (Haloperidol) Injection BP 5mg/ml.
Concordia International. (16 December 2015). Adrenaline Injection BP 1/1000 (1mg/1ml) (epinephrine).
Ferring Pharmaceuticals limited. (November 2011). Pabal 100 micrograms in 1 ml solution for injection. Wittland Kiel, Germany.
Ferring Pharmaceuticals limited. (October 2012). Glypressin 1mg powder and solvent for solution for injection (Terlipressin). Wittland, Kiel: Germany.
Fresenius Kabi Manufacturing SA (Pty) Ltd. (2015). Aminophylline IV Fresenius 250mg injection (aminophylline hydrate 25mg/ml solution for injection).
Fresenius Kabi Manufacturing SA (Pty) Ltd. (31 March 2015). Neostigmine methylsulfate Injection BP 2.5mg in 1 ml.
Fresenius Kabi Manufacturing SA (Pty) Ltd. (9 December 2008). Phenergan Injection (Promethazine hydrochloride) or Promethazine HCl Fresenius 25mg or Promethazine HCl Fresenius 50 mg. Gibaud Road, Korsten, Port Elizabeth, South Africa, 6020.
Fresenius Kabl Deutschland GmbH. (2017). Propofol 1% MCT/LCT Fresenius emulsion for injection (Diprivan 10mg/ml emulsion for injection or infusion. Manufactured by Fresenius Kabl Austria GmbH, Rapsgatan, Uppsala: Sweden.
GlaxoSmithKline. (05 February 2015). Ventolin Injection 500mcg solution for injection (salbutamol). Strada Provincial Asolana, San Polo di Torripe: Parma, Germany.
GlaxoSmithKline. (07 June 2016). Fortum 1g for injection (Ceftazidime. Strada Provincial Asolana, San Polo di Torripe: Parma, Germany.
GlaxoSmithKline. (07 May, 2014). Nimbex Injection 2mg/ml (Cisatracurium besylate). Strada Provincial Asolana, San Polo di Torripe: Parma, Germany.
GlaxoSmithKline. (28 February 2015). Flolan 1.5mg powder and solvent for solution for infusion (with pH of 10.5 solvent). Strada Provincial Asolana, San Polo di Torripe: Parma, Germany.
GlaxoWellcome. (2015). Zinacef 1.5g powder for solution (cefuroxime sodium).
Gray, A. H. (2009). Injectable drugs pocket companion. London: Pharmaceutical; Press.
Gray, A. H., Wright, J., Bruce, L., & Oakley, J. (2016). Clinical pharmacy: pocket companion. London: Pharmaceutical Press. Print Book: English
Hameln Pharmaceuticals Ltd. (07 September, 2014). Fentanyl 50 microgram/ml injection.
Hikma. (06 May, 2014). Phenytoin Hikma 50 mg/ml solution for injection. Kent Pharmaceuticals.
Hospira Inc. (2004). Dobutamine concentrate 250/20ml solution for infusion (also available in 5mg/ml). Lake Forest, USA.
Hospira limited. (August 2011). Glyceryl trinitrate 5 mg/ml sterile concentration. Queensway, Royal Leamington Spa, Warwickshire: UK
Hospira Limited. (June 2015). Vancomycin hydrochloride for injection, USP. Queensway, Royal Leamington Spa, Warwickshire: UK
Hospira Limited. (November, 2015). Dopamine 40 mg/ml sterile concentrate. Queensway, Royal Leamington Spa, Warwickshire: UK
Hospira Limited. (October 2016). Levophed (Norepinephrine Bitartrate injection USP). Queensway, Royal Leamington Spa, Warwickshire: UK
Hospira Limited. (September 2016). Pamidronate Disodium 9mg/ml Sterile Concentrate Queensway, Royal Leamington Spa, Warwickshire: UK
Janssen-Cilag Limited. (26 May 2016). Rapifen 500 micrograms/ml solution for injection for infusion (alfentanil hydrochloride)
Julphar. (August 2015). Miacin: Amikacin Sulphate for parenteral use. Gulf Pharmaceutical Industries, Ras Al Khaimah, U.A.E.
Made for F. Hoffmann-La Roche Limited, Basel Switzerland. (August 2014). Anexate 0.1mg/ml solution for injection (flumazenil). Made by CENEXI SAS, Fontenary-sous-Bois, France.
Martindale Pharmaceuticals. (10 January 2017). Atropine Sulfate Injection 600 mcg in 1 ml ampoules. Bampton Road, Harold Hill: Rumford, UK.
Martindale Pharmaceuticals. (15 December 2016). Ephedrine hydrochloride 30 mg per 1 ml solution for injection. Bampton Road, Harold Hill; Rumford: England
Merck & CO, Inc. Elkton USA for Merck Sharp & Dohme. (21 February 2008). Tienam (Imipenem/ cilastatin 500mg/500mg powder for solution for injection). Whitehouse Station. New Jersey, USA.
Merck Sharp & Dohme Limited. (11 June 2015). Remicade 100mg powder for concentrate for solution for infusion (infliximab).
Merck Sharp & Dohme Limited. (23 June 2016). Cancidas (Formerly caspofungin MSD)50 mg, 70 mg powder for concentrate for solution for infusion.
Norvatis Pharma AG. (November 2011). Methergin (Methylergonovine or methylergometrine maleate 0.2mg). Basle, Switzerland.
Norvatis pharmaceuticals Limited. (18 February 2016). Syntocinon 10 IU/ml concentrate for solution for infusion. Basel, Switzerland.
Novartis Pharmaceuticals Limited. (31st January, 2017). Zofran Injection, Flexi-Amp Injection. BGP Products Limited.
Novo Nordisk Limited. (2016). Novoseven 1mg, 2mg, 5mg and 8mg powder and solvent for solution for injection.
Organon. (2016). Esmeron 10 mg/ml, solution for injection.
Patheon Italia S.p.a. (05 January 2017). Keppra 100 mg/ml concentrate for solution for infusion: levetiracetam. Manufactured for GlaxoSmithKline Export Limited
Patheon Italia S.p.A. (January 2011). Tygacil 50mg powder for solution for infusion (for intravenous use). (Tigecycline). packaged and released by Wyeth Lederie S.p.A; Marketing authorization holder: Pfizer Limited.
Patheon Manufacturing Services LLC. (03 December, 2014). Aggrastat 50 mcg/ml solution for infusion. North Carolina, USA. Packaged in Zouk Mosbeh, Lebanon, by Algorithm S.A.L.; a registered trademark of Cardiome International AG.
Pfizer Health AB. (April 2008). Cyklokapron injection 500mg tranexamic acid. (Tranexamic acid 100mg/ml solution for injection). Stockholm, Sweden.
Pfizer limited. (16 December 2013). Diflucan 2 mg/ml solution for infusion. Puurs, Belgium.
Pfizer limited. (July 2014). Dalacin C phosphate sterile solution. Puurs, Belgium.
Pfizer Manufacturing Belgium NV. (04 August 2010). Solu-medrone sterile powder 40mg (Methylprednisolone sodium succinate). Puurs, Belgium.
Pfizer Manufacturing. (2017). Prostin E2 Sterile solution 10mg/ml intravenous (each ml contains 10mg Dinoprostone). Belgium NV; Puurs: Belgium.
Roche products limited. (2 September 2015). Rocephin 250mg powder for solution for injection, 1g powder for solution for injection or infusion, 2g powder for solution for injection or infusion.
Roche Products limited. (27 September 2016). Konakion MM 10 mg/ml. Manufactured for F. Hoffmann-La Roche SA, Basel, Switzerland, by CENEXI SAS, Fontenay-sous-Bois, France
Roche. (February 2013). Dormicum: Midazolam 1 mg/ml solution for injection for infusion. Manufactured for F. Hoffmann-La Roche SA, Basel, Switzerland, by CENEXI SAS, Fontenay-sous-Bois, France
Sandoz (2010). Piperacillin/tazobactam Sandoz 4.5g powder for solution for injection or infusion.
Sandoz. (2007). Curam 1.2g IV powder for solution for injection/infusion.
Sandoz. (September 2016). Gentamicin Sandoz 40mg/80mg ampoules.
Sanofi Aventis Deutschland. (July 2012). Tavanic 5mg/ml solution for infusion (Levofloxacin). Frankfurt am Main, Germany.
Sanofi Aventis. (14 November 2013). Adenocor 3mg/ml solution for injection: adenosine. Frankfurt am Main, Germany
Sanofi. (18 January 2012). Lasix Injection 20 mg/ml. Frankfurt am Main, Germany
SPIMACO. (June 2009). GENTAM 80, GENTAM 20, 80mg, 20mg Gentamicin Injection IM/IV. Manufactured by SPIMACO: Al-Qassim Pharmaceutical Plant: Saudi Pharmaceutical industries & Medical Appliances Corporation, Saudi Arabia.
Stada, (April 2014). Tramal 50mg, solution for injection (tramadol hydrochloride).
Trandate. (19 August 2016). Trandate labetalol: 5mg/ml labetalol hydrochloride solution for injection.
Trissel, L. A., & American Society of Health-system Pharmacists. (2011). Handbook on injectable drugs. Bethesda, M.D.: American Society of Health-System Pharmaceutical.
Troge. (April 2016). Dexamethasone 3.3 mg/ml solution for injection. Hamburg, Germany.
Wockhardt Limited. (October 2011). Hyalase 1500IU powder for solution for injection/infusion (Hyaluronidase). Ash Road North, Wrexham.
Antibiotice SA. (2014). Ampicillin 500mg vials for injection. Valea Lupul, Romania: EU.